Alu Monomer Revisited: Recent Generation of Alu Monomers
نویسندگان
چکیده
منابع مشابه
Alu monomer revisited: recent generation of Alu monomers.
Alu is a predominant short interspersed element (SINE) family in the human genome and consists of two monomer units connected by an A-rich linker. At present, dimeric Alu elements are active in humans, but Alu monomers are present as fossilized sequences. A comparative genome analysis of human and chimpanzee genomes revealed eight recent insertions of Alu monomers. One of them was a retroposed ...
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Alu elements are a family of short interspersed repeats that have mobilized throughout primate genomes by retrotransposition over the past 65 Myr of primate evolution (for a review, see Deininger and Batzer 1993). In the human genome, Alu elements exist in copy numbers of approximately 500,000 per haploid genome, representing approximately 5% of the genome, and they may be classified into group...
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Alu elements are the most abundant repetitive elements in the human genome; they emerged from the signal recognition particle RNA gene and are composed of two related but distinct monomers (left and right arms). Alu RNAs transcribed from these elements are present at low levels at normal cell growth but various stress conditions increase their abundance. Alu RNAs are known to bind the cognate p...
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The proposed project implementation is on AMBA IO System. The bus interface used in the project is AXI Interface Bus. Master and Slave interfaces will be developed according to the proposed AMBA design. The description of the AMBA protocol and various blocks are mentioned below. The Advanced Microcontroller Bus Architecture (AMBA) specification defines an on-chip communications standard for des...
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Alu repeats contribute to genomic instability in primates via insertional and recombinational mutagenesis. Here, we report an analysis of Alu element-induced genomic instability through a novel mechanism termed retrotransposition-mediated deletion, and assess its impact on the integrity of primate genomes. For human and chimpanzee genomes, we find evidence of 33 retrotransposition-mediated dele...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2010
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msq218